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35–65% of tube fed patients experience intolerance in Canada1

Tube feeding or enteral nutrition (EN) intolerance is reported to affect patient quality of life and to reduce EN volume delivered – which may result in nutrition deficits, dehydration and malnutrition.2

PEPTAMEN® is designed for tolerance and absorption:

  • 100% whey protein remains liquid in an acidic environment to help facilitate gastric emptying and reduce reflux3-6
  • Small protein units, with <1% intact protein, enhance absorption7-9
  • Lipid blends with 50–70% MCT enhance fat absorption10-13

Protein Source

  • PEPTAMEN® formulas are the only enteral nutrition formulas with 100% whey protein.
  • Whey protein has multiple attributes, which can support gastrointestinal tolerance, muscle protein synthesis, and blood glucose management.

Protein Form

  • PEPTAMEN® contains hydrolyzed whey protein (<1% intact protein).

  • Small protein units or peptides facilitate digestion and absorption to help with tolerance.

Protein Amount

  • PEPTAMEN® family of products offer a range of protein levels to meet different nutritional needs.
  • Facilitates delivery of protein targets.

What are some symptoms of tube feeding intolerance?

Symptoms of intolerance may include,
but are not limited to, the following:

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CLICK HERE for PEPTAMEN® and Managing Intolerance Infographic

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Enteral Nutrition Intolerance Beyond the ICU Janet Madill, PhD, RD

Enteral nutrition intolerance (ENI) or tube feeding intolerance has been reported as the most common complication associated with tube feeding. This Canadian study examines the prevalence and management of ENI in patients and individuals outside the ICU.

A Nurse’s Guide to Minimizing Tube Feed Intolerance Alice Atcher, BSc, RN, CCRN, CRNI

The benefits of early tube feeding in the ICU, barriers that may impede the delivery of early and adequate nutrition, and strategies to help minimize enteral feeding intolerance – presented from a nursing perspective.


Prevalence and Management of Enteral Nutrition Intolerance in the Non-ICU Setting in Canada Hopkins B et al. CJCN. 2017; 5(2): 82-101.

Enteral nutrition (EN) intolerance, described as one or more gastrointestinal (GI) symptoms, is reported to affect patient quality of life and reduce EN volume delivered, which may result in nutrition deficits, dehydration and malnutrition. This study examines the prevalence and management of EN intolerance outside of the ICU setting.


Tube Feeding Intolerance – Troubleshooting Guide

Use the checklist to help determine if your patient may be experiencing tube feeding intolerance and to track severity and duration of symptoms. Refer to the Troubleshooting Guide for solutions to consider for managing intolerance symptoms.

Your Guide to Home Tube Feeding

Patient information about managing tube feeding at home. This guide is intended to support the tube feeding advice and instruction provided by healthcare professionals.

PEPTAMEN® Starter Booklet

Information for the patient/family on why nutrition is important and specific considerations for individuals with gastrointestinal impairment. This booklet also contains information about how PEPTAMEN® is designed for gastrointestinal tolerance and absorption – in tube feeding or oral use.


Patients may present with a number of conditions, which may lead to higher protein needs. When a combination of these factors exists, it can have a profound influence on the protein needs of patients.



1. Hopkins B et al. CJCN. 2017;5(2):82-101. 2. Bernard AC et al. NCP. 2004;19:481-486. 3. Fried MD et al. J Pediatr. 1992;120:569-72. 4. Khoshoo V et al. Eur J Clin Nutr. 2002;56:1-3. 5. Dangin M et al. J of Nutr. 2002;S3228-33. 6. Abrahao V. Curr Opin Clin Nutr Metab Care. 2012;15:480-484. 7. Grimble GK. Annu Rev Nutr. 1994;14:419-47. 8. Hannelore D. Annu Rev Physiol. 2004;66:361-84. 9. Maples B. JPEN. 2005;29:51. 10. Malone A et al. in Mueller C (Ed). 2012. Core Curr ASPEN. 11. Martindale R et al. in Gottschlich M (Ed). 2007. Core Curr ASPEN. 12. Hise M & Brown J. in Mueller C (Ed). 2012. Core Curr ASPEN. 13. Colaizzo-Anas T. in Mueller C (Ed). 2012. Core Curr ASPEN. 14. Little JP & Phillips SM. Appl Physiol Nutr Metab. 2009;34:817-828. 15. Moisey LL et al. Critical Care. 2013;17:R206. 16. Cruz-Jentoft AJ et al. Age and Ageing. 2010:1-12. 17. Fearon K et al. J Cachexia Sarcopenia Muscle. 2011;2:1-3. 18. Breen L & Phillips SM. Nutr & Metab. 2011;8(68):e-version. 19. Adams RL & Broughton KS. Ann Nutr Metab. 2016;69:56-63. 20. Ochoa JB et al. JPEN. 2017;41(2):289. 21. McClave SA et al. JPEN. 2015;39(2):240.

PEPTAMEN® Product Guide

For information on all Nestlé Health Science products: Nestlé Health Science Product Guide